Regulatory networks in Leishmania major

The metabolic pathways mentioned in BioCyc were taken into account to form an interacting regulatory network of genes, to lay an emphasis upon the clustering of the genes into metabolic pathways of related functions.

From this network it was clearly visible, that LPG Biosynthetic Pathway, GIPL Biosynthesis Pathway, GPI anchor Biosynthesis Pathway, and Dolichyl-diphosphooligosaccharide biosynthesis Pathway were inter-connected through 1 or more genes involved commonly in the regulation of the proteins which act as enzymes catalyzing the reactions in these pathways. Hence, the gene regulatory network gives an entire overview about the reacting species in the same dimension. We can illustrate and investigate the reactions and pathways that are inter-connected and have common enzymes and compounds taking part in the same reactions. It gives an outline and a general idea related to the cluster of genes taking part in the reactions.

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Regulatory network in Schistosoma mansoni:

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Biochemical Modeling

Since it was established that the Lipophosphoglycan Biosynthetic Pathway posed a vital role in the Leishmania Parasite, and was a significant Pathway for identifying the drug targets, it was reconstructed for generating a Mathematical Model. The genes coding for the enzymatic proteins, substrates, products, Enzyme-substrate complex, and the metabolites all the entities were taken into account during the rebuilding of the pathway. The reactions involved were the state transition for Substrate to ES complex and ES complex to product; catalysis for the enzyme catalyzing the reaction, and the known transition omitted for the gene to protein reaction.

Mathematical modeling of LPG Biosynthetic Pathway in Leishmania major

Gene Details for Regulatory network in Schistosoma mansoni

Glycerophospholipid Metabolism in Schistosoma mansoni